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Thus, while exposure with a positive coefficient would increase the disutility score, it would decrease the HRQoL scores and worsen the health state 23

A systematic review of medical interventions for oral submucous fibrosis and future research opportunities

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Table 3 GRADE assessment for certainty of evidence for association between chewing and smoking forms of tobacco with oral potentially malignant disorders and oral malignancy with mixed and no mixed tobacco usage Figure 6 Funnel plots for studies included in the pooled analysis DISCUSSION This meta-analysis is the first in scientific literature to evaluate and assess the differences in association between tobacco smokers and chewers with oral cancer or oral potentially malignant disorders